Histopathological study on the effect of Artemisinin multiple doses on the pathogenesis and immune reaction of Trichinella spiralis in albino rats

Document Type : Original Articles

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1 Pathology department, Faculty of Veterinary Medicine, Mansoura University, Egypt

2 Department of Pathology, Faculty of Veterinary medicine, Mansoura University

Abstract

Objective: The aim of this study was to determine the therapeutic effect of Artemisinin multiple doses on the pathogenesis and immune reaction of Trichinella spiralis during the intestinal and muscular phases in albino rats.
Design: Randomized controlled study.
Animal Models: The experiment was performed on 80 adult albino rats of both sexes, weighting (160 g ±20g) and (4-6) weeks old.
Procedures: rats were divided into four experimental groups, (Control negative) group, T. spiralis infested (TR) group: each animal was orally infested with 300 T. spiralis larvae, T. spiralis treated (AR+TR) group: each animal in this group was orally infested with 300 T. spiralis larvae followed by treatment with Artemisinin at dose of (400 mg / kg body weight) one day PI for three successive days and other three successive doses on days 21, 22 and 23 PI, (AR) group, animals received Artemisinin only at the same dose.
Results: The current study recorded that AR administration showed improvement of the histopathological and ultra-structural alterations of the intestine during the intestinal phase. In addition to its efficacy in decreasing the larval count during the muscular phase. But showed minimal improvement in the histopathological and ultra-structural alterations of the infected skeletal muscles without improvement in the biochemical and hematological findings
Conclusion: Artemisinin had significant anthelminthic efficacy against the adult stage of T. spiralis during the intestinal phase and minimal efficacy against encysted muscle larvae

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