Adverse effect of Nitroxynil and Albendazole on rabbits

Elalfy, Eman; Hassan, Azza; Amer, Magdy

doi:10.21608/mvmj.2021.215026

Adverse effect of Nitroxynil and Albendazole on rabbits

Document Type : Original Articles

Authors

¹ Animal Health Research Institute, Mansoura

² Pharmacology Department, Faculty of Veterinary Medicine, Mansoura University, 35516, Egypt

10.21608/mvmj.2021.215026

Abstract

Objective:The present study aims to investigate the possible adverse effects of the subcutaneous injection of nitroxynil and oral administration of albendazole in rabbits.
Design:Randomized controlled experimental study.
Animals: 18 New Zealand rabbits of 1.50 ± 0.5 kg body weight, were allocated randomly into three groups (n=6).
Procedures: Group A served as control, the group B was treated with albendazole (20 mg /kg B. wt.) orally and the group C was treated with nitroxynil (10mg /kg B. wt.) subcutaneously. Blood samples were collected at 1^st, 7^th and 14^th days post drugs administration for hematological and biochemical determination. In addition, histopathological examination of liver, kidney and intestine specimens were performed.
Results:The obtained results evoked a significant decrease in RBCs, PCV, Hb, WBCs, lymphocytes , neutrophils, GSH and catalase values in group B and C compared with that group A. On the other hand, group B and C elevated serum ALT, AST, urea, creatinine, and MDA significantly (P ≤0.05) compared with group A

Keywords

Main Subjects

Pharmacology and toxicology

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