Sedative, analgesic and behavioral changes of caudal epidural injection of xylazine, magnesium sulphate in Egyptian water buffalo (Bubalus bubalis)

Document Type : Original Articles

Authors

1 surgery, Anesthesiology & Radiology, Faculty of Veterinary Medicine, Benha University, Benha, Egypt

2 Department of Veterinary Surgery, Anesthesiology and Radiology, College of Veterinary Medicine, Monofia University, Shebin El-Kom, Egypt

3 Department of Animal Medicine, College of Veterinary Medicine, Benha University, Benha, Egypt

4 Department of Pharmacology, College of Veterinary Medicine, Benha University, Benha, Egypt

5 Department of Veterinary Hygiene and Management, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.

Abstract

Objective: To assess and compare the effects of epidural xylazine (XY), magnesium sulphate (MG) and their combination (XY-MG) in buffalo.
Design: Crossover study
Animals: Seven healthy, non-pregnant buffalo
Procedures: Buffaloes were allocated into one of three groups in a prospective randomized crossover design with two weeks washout period as the following: XY group, MG group and XY-MG group. The sedative, analgesic, and behavioral effects of XY, MG and their combination were evaluated prior to administration and at then after injection at 5, 10, 15, 30, 45, 60, 90 120, 150, 180, and 210 minutes.
Results: Clinical and hematological variables were evaluated at baseline (0 minute) and then at 15, 30, 45, 60, 90, 120, 180, and 210-minutes post-administration. Buffaloes received XY-MG combination showed the fastest onset and resulted in the longer duration of epidural analgesia. The longest duration of complete sedation was recorded in group XY-MG. All treatment protocols caused mild ataxia and affected the heart rate, respiratory rate and rectal temperature of buffalo. There was a significant decrease in the blood glucose at 30 minutes after injection in all groups, returning to the baseline level by 180 minutes in XY-MG group and 210 minutes in XY and MG groups.
Conclusion and clinical relevance:  XY-MG combination may be used as epidural sedative and analgesic to control pain in buffalo.

Keywords

Main Subjects


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]1[ Saifzadeh S, Pourjafar M, Naghadeh BD et al. Caudal Extradural Analgesia with Lidocaine, Xylazine, and a Combination of Lidocaine and Xylazine in the Iranian River Buffalo.  Bull Vet Inst Pulawy. 2007; 51: 285–288.

]2[  Lin H. Pain management for farm animals. Farm Animal Anesthesia: Cattle, Small Ruminants, Camelids, and Pigs. 2014; 174-214.‏ https://doi.org/10.1002/9781118886700.ch9

]3[  Ismail ZB. Epidural analgesia in cattle, buffalo, and camels. Vet World. 2016; 12: 1450–1455. https://doi.org/10.14202/vetworld.2016.1450-1455

]4[  Lardone E, Peirone B, Adami C. Combination of magnesium sulphate and ropivacaine epidural analgesia for hip arthroplasty in dogs. Vet Anesth Analg. 2017; 44: 1227–1235. https://doi.org/10.1016/j.vaa.2016.11.016

]5[  Straticò P, Varasano V, Suriano R et al. Analgesic effects of intravenous flunixin and intrafunicular lidocaine or their combination for castration of lambs. Vet Rec Open. 2018; 5: 1–10. https://doi.org/10.1136/vetreco-2017-000266

]6[ Ismail ZB, Abu-Basha E, Alzghoul A. Epidural co-administration of neostigmine and lidocaine or xylazine enhances systemic sedation but not perineal analgesia in adult dairy cows.  Vet Med Czech Acad Agr Sci. 2018; 63: 306–312. https://doi.org/10.17221/25/2018-VETMED

]7[  Kayode OA. Studies on Epidural anesthesia using lidocaine with Adrenaline on Haemato-biochemical responses in pregnant West African Dwarf goats. J Med Res. 2017; 6: 012–015. https://doi.org/10.18685/EJMR(6)2_EJMR-17-012

]8[  Grubb TL, Riebold TW, Crisman RO. Comparison of lidocaine, xylazine, and lidocaine−xylazine for caudal epidural analgesia in cattle.  Vet Anaesth Analg. 2002; 29: 64–68. https://doi.org/10.1046/j.1467-2995.2001.00068.x

]9[  Azari O, Seyyedin S, Molaei, MM. Analgesic and sedative effects of caudal epidural tramadol in dromedary camels.  Bulg J Vet Med. 2019; 22: 57–65. https://doi.org/10.15547/bjvm.2052

]10[  Skarda RT, Tranquilli WJ. Lumb and Jones Veterinary Anesthesia and Analgesia. Ames, Iowa, USA: Blackwell Publishing; 2007. [Google Scholar]

]12[  Garcia Pereira FL, Greene SA, McEwen MM, Keegan R.  Analgesia and anesthesia in camelids. Small Rumin Res. 2006; 61: 227-233. https://doi.org/10.1016/j.smallrumres.2005.07.013.

]13[  Liotta A, Busoni V, Carrozzo MV et al. Feasibility of ultrasound-guided epidural access at the lumbo-sacral space in dogs. Vet Radiol Ultrasound. 2015; 56: 220–228. https://doi.org/10.1111/vru.12207

]14[  Ladha A, Alam A, Idestrup C, Sawyer J, Choi S. Spinal haematoma after removal of a thoracic epidural catheter in a patient with coagulopathy resulting from unexpected vitamin K deficiency. Anaesthesia. 2013; 68: 856-860.‏ https://doi.org/10.1111/anae.12285

]15[  Pumberger M, Memtsoudis SG, Stundner O, et al. An analysis of the safety of epidural and spinal neuraxial anesthesia in more than 100,000 consecutive major lower extremity joint replacements. Reg Anesth Pain Med. 2013; 38: 515-519.‏ https://doi.org/10.1097/AAP.0000000000000009

]16[  Singh P, Pratap K, Amarpal, et al. Effects of xylazine, lignocaine and their combination for lumbar epidural analgesia in water buffalo calves (Bubalus bubalis). J S Afr Vet Assoc. 2005b; 76: 151-158.‏ https://doi.org/10.4102/jsava.v76i3.417

]17[  Sharshar A, Abedellaah B, Shoghy K et al. Dorsolumbar Epidural Analgesia in Water Buffalo: Anaesthetic Assessment and Anatomical Studies.  Alex J Vet Sci. 2015; 45: 63. https://doi.org/10.5455/ajvs.182790

]18[Sarrafzadeh-Rezaei F, Rezazadeh F, Behfar M. Comparison of caudal epidural administration of lidocaine and xylazine to xylazine/ketamine combination in donkey (Equus asinus). Iranian Journal of Veterinary Surgery. 2007; 2: 7-16.‏

]19[  Singh V, Kinjavdekar P, Aithal H P. Effect of bupivacaine on epidural analgesia produced by xylazine or medetomidine in buffaloes (Bubalus bubalis). Veterinary anaesthesia and analgesia. 2009; 36: 77-85.‏ https://doi.org/10.1111/j.1467-2995.2008.00429.x

]20[  Khalil AH, Abd Al-Galil AS, Sabek AA et al. Sedative, analgesic, behavioral and clinical effects of intravenous nalbuphine-xylazine combination in camels (Camelus dromedarius). J VET SCI. 2019; 20: 1-9. https://doi.org/10.4142/jvs.2019.20.e55

]21[  Dubé L, Granry JC . The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: A review.  Can J Anesth. 2009; 50: 732–746. https://doi.org/10.1007/BF03018719

]22[  Bhatia A, Kashyap L, Pawar DK, Trikha A. Effect of intraoperative magnesium infusion on perioperative analgesia in open cholecystectomy. J Clin Anesth. 2004; 16: 262-265. https://doi.org/10.1016/j.jclinane.2003.08.012

]23[  Bahrenberg A, Dzikiti BT, Fosgate GT. Antinociceptive effects of epidural magnesium sulphate alone and in combination with morphine in dogs.  Vet Anaesth Analg. 2015; 42: 319–328. https://doi.org/10.1111/vaa.12211

]24[  Herroeder S, Schönherr ME, De Hert SG, Hollmann MW. Magnesium-essentials for anesthesiologists. Anesthesiology. 2011; 114: 971-993. https://doi.org/10.1097/ALN.0b013e318210483d

]25[  Sadegh AB, Shafiei Z, Nazhvani SD. Comparison of epidural anesthesia with lidocaine-distilled water and lidocaine-magnesium sulfate mixture in goat.  Veterinarski Arhi. 2009; 79: 11–17.

]26[  Sadegh AB, Shafiei Z. Comparison of Caudal Epidural Anesthesia with Mixture in Horses.  J Equine Vet Sci. 2008; 28: 341–344. https://doi.org/10.1016/j.jevs.2008.04.011

]27[  Dehghani SN, Bigham AS. Comparison of caudal epidural anesthesia by use of lidocaine versus a lidocaine–magnesium sulfate combination in cattle. Am J Vet Res. 2009; 70: 16–19. https://doi.org/10.2460/ajvr.70.2.194

]28[  Marzok MA, El-khodery SA. Comparative analgesic and sedative effects of tramadol, tramadol-lidocaine and lidocaine for caudal epidural analgesia in donkeys (E quus asinus). Vet Anaesth Analg. 2015; 42: 215-9. https://doi.org/10.1111/vaa.12195

]29[  Yousef AA, Amr YM. The effect of adding magnesium sulphate to epidural bupivacaine and fentanyl in elective caesarean section using combined spinal – epidural anaesthesia; a prospective double blind randomised study.  Int J Obstet Anesth. 2010; 19: 401–404. https://doi.org/10.1016/j.ijoa.2010.07.019

]30[  Fawcett WJ, Haxby EJ, Male DA. Magnesium: Physiology and pharmacology. Br J Anaesth. 2003; 83: 302-320.‏ https://doi.org/10.1093/bja/83.2.302

]31[  Buvanendran A, McCarthy RJ, Kroin JS, et al. Intrathecal magnesium prolongs fentanyl analgesia: A prospective, randomized, controlled trial. Anesth Analg. 2002; 95: 661-666. https://doi.org/10.1213/00000539-200209000-00031

]32[  Bilir A, Gulec S, Erkan A, Ozcelik A. Epidural magnesium reduces postoperative analgesic requirement. Br J Anaesth. 2007; 98: 519-523. https://doi.org/10.1093/bja/aem029

]33[  DeRossi R, Pompermeyer CTD, Silva-Neto AB, et al. Lumbosacral epidural magnesium prolongs ketamine analgesia in conscious sheep. Acta Cir Bras. 2012; 27: 137-143. https://doi.org/10.1590/S0102-86502012000200007

]34[  Bahar M, Chanimov M, Grinspun E. Spinal anaesthesia induced by intrathecal magnesium sulphate. Anaesthesia. 1996; 51: 627-633. https://doi.org/10.1111/j.1365-2044.1996.tb04643.x

]35[  Shukla D, Verma A, Agarwal A et al. Comparative study of intrathecal dexmedetomidine with intrathecal magnesium sulfate used as adjuvants to bupivacaine.  J Anaesthesiol Clin Pharmacol. 2011; 27: 495–499. https://doi.org/10.4103/0970-9185.86594

]36[  Singh P, Kinjavdekar AP, Aithal HP, Singh GR. Haemodynamic and electrocardiographic effects of xylazine, ketamine, lidocaine and their combinations after lumbar epidural administration in healthy buffalo calves. J APL ANI Res. 2005a; 28: 101-106. https://doi.org/10.1080/09712119.2005.9706801

]37[  Kästner SB. A2-agonists in sheep: A review.  Vet Anesth Analg. 2006; 33: 79–96. https://doi.org/10.1111/j.1467-2995.2005.00243.x

]38[  Kinjavdekar, Singh GR, Aithal et al. Physiologic and biochemical effects of subarachnoidally administered xylazine and medetomidine in goats. Small Ruminant Research: J Int Goat Assoc. 2000; 38: 217–228. https://doi.org/10.1016/S0921-4488(00)00161-9

]39[  Valverde A. Alpha-2 Agonists as Pain Therapy in Horses.  Vet Clin North Am Equine Pract. 2010; 26: 515–532.

]40[  Sinclair MD. A review of the physiological effects of α2-agonists related to the clinical use of medetomidine in small animal practice.  Can Vet J. 2003; 45: 475–480. https://doi.org/10.1016/j.cveq.2010.07.003

4]1[  Roffe C, Fletcher S, Woods KL. Investigation of the effects of intravenous magnesium sulphate on cardiac rhythm in acute myocardial infarction. Br Heart J. 1994; 71: 141-145. https://doi.org/10.1136/hrt.71.2.141

]42[  Kiran S, Gupta R, Verma D. Evaluation of a single-dose of intravenous magnesium sulphate for prevention of postoperative pain after inguinal surgery. Indian J Anaesth. 2011; 55: 1. https://doi.org/10.4103/0019-5049.76605

]43[  Moulvi B A, Parrah J. D., Kalim M. O., Athar H., Dedmari F. H. Haemato-biochemical response to lignocaine alone or in combination with xylazine for epidural analgesia in cow calves. J  Advanced Vet Res 2011; 1: 17-20. https://doi.org/10.5455/vetworld.2011.364-367

]44[  Araújo MA, Albuquerque VB, Deschk M. Cardiopulmonary and analgesic effects of caudal epidurally administered ropivacaine in cattle. Vet Anaesth Analg. 2012; 39: 31-35. https://doi.org/10.1111/j.1467-2995.2012.00726.x

]45[  Potliya S, Kumar A, Kumar S et al. Evaluation of efficacy and safety of glycopyrrolate-xylazine-propofol anesthesia in buffalo calves. Vet world. 2015; 8: 251. https://doi.org/10.14202/vetworld.2015.251-256