Teratogenic effect of fluconazole on rabbit’s foeti

Document Type : Original Articles


1 Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

2 animal health research institute, Mansoura

3 Pharmacology Department, Faculty of veterinary medicine, Mansoura university

4 Animal health research institute, Zagazig

5 2Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt


Objective: The current study was designed to assess the teratogenic effect of fluconazole on developing rabbits’ foeti
Design: Randomized controlled study.
Animals: Twenty-four sexually mature females and 2 adult males New Zealand white rabbits, 5- 6 months old, weighing 3-4 kg, were used in this study. The mature males were used for mating process
Procedure: The pregnant female rabbits (24) were allotted into 4 groups (6 rabbits/ group). Control group (G1) administered normal saline. Other groups were given fluconazole orally at a dose 80 mg/kg once daily for ten days either on the first stage (G2), the second stage (G3), or the third stage (G4) of gestation period. Three dams were sacrificed from every group (n=3) on the 20th and 30th day of gestation. The influence of fluconazole on the developing foeti was investigated grossly and histopathologically.
Results: Administration of fluconazole during gestation caused significant reduction (P < 0.05) in the mean values of viable foeti, fetal body weight and crown-rump length, and significant elevation (P < 0.05) in the mean values of dead foeti, fetal resorption rate, pre- and post-implantation death. Additionally, visceral fetal abnormalities were noticed including; thickened ventricles of the heart, and dilated lateral ventricles of brain. Moreover, fluconazole induced skeletal anomalies in the developing foeti shown as absence of last rib.
Conclusion and clinical relevance: The prescription of fluconazole must be prevented during pregnancy to avoid fetal malformations.


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