IMPACT OF INSULIN PRODUCING STEM CELLS DERIVED from HUMAN BONE MARROW ON SOME DIABETIC COMPLICATIONS

Document Type : Original Articles

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1 Department of physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

2 Urology and Nephrology center, Mansoura University, Mansoura, Egypt

Abstract

Stem cells were derived from adult human bone marrow. After differentiation cells were encapsulated in the rectus abdominus sheath of diabetic dogs. Eighteen mongrel dogs were divided into three groups: normal non-diabetic group (6), diabetic untreated group (6), and treated group (6). Blood glucose levels was improved to be like normal range in diabetic dogs treated with stem cells. Lipid profile including triacylglycerol, HDL-C, LDL-C and cholesterol levels were significantly higher in diabetic untreated dogs and showed a significantly lowered levels in stem cells treated dogs than that in diabetic dogs and become nearly to normal dogs. ALT activities of diabetic dogs with treatment slightly improved than non- diabetic and diabetic untreated groups while AST activities returned to be as in normal group. Creatinine levels of untreated diabetic dogs was significantly higher than those of treated diabetic dogs and improved to be as in normal dogs. In this study, we successfully induced the differentiation of MSCs into functional insulin producing cells (IPCs) by transplanting IPCs into chemically induced diabetic dogs, it was found that IPCs were capable to improve blood glucose levels and so decrease the lipid profile, kidney function and liver function. Keywords: Dog, Hyperlipidemia, Lipid profiles, liver function, Kidney function, stem cells, diabetes mellitus.

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