Effects of Rosemary and husk on hemogram and some biochemical parameters during treatment of ulcerative colitis in rats

Document Type : Original Articles

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1 Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

2 Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt

Abstract

Objective: The effects of rosemary (10 mg/kg B.W) and husk (5 mg/kg B.W) on hemogram, GSH , CAT , NO, IL-1β and IL-10 of rats (40 albino rats) were investigated Design:Experimental study Animals: 40 albino rats Procedures: The 1st group was served as negative control, while the remaening groups (2nd, 3rd and 4th) were given acetic acid (4%) to induce ulcerative colitis (UC). Then the 2nd group was used as positive control, the 3rd group was orally given rosemary daily for 7 days, while the 4th group was orally administerated husk daily for 7 days. Blood and serum samples were collected from all groups at one week post dosing Results: The obtained results revealed that, both the tested plants induced a significant increase in RBCs, Hb, PCV% and lymphocyte counts and a significant decrease in WBC, neutrophil, monocyte and blood platelets of treated rats compared with the positive control group. Conclusion and clinical relevance: In addition rosemary and husk evoked a significant increase in GSH, CAT and IL-10 and a significant decrease in NO and IL-1β in serum of treated rats in comparions with the positive control group.

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