EFFECT OF ANTIOXIDANTS SUPPLEMENTATION ON HORSES WITH ACUTE AND CHRONIC INFLAMMATORY AIRWAY DISEASE

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The aim of the present study was to evaluate the effect of antioxidants supplementation on horses with inflammatory airway disease (IAD). For this purpose, venous blood samples were collected from (40) horses exhibiting signs of acute and chronic IAD. Plasma total antioxidant capacity (TAC), reduced glutathione (GSH), uric acid, superoxide dismutase (SOD), vitamin C, malondialdehyde (MDA), nitric oxide (NO), urea, low density lipoprotein (LDL) and catalase (CAT) were assayed. Biochemically, there was a significant increase in TAC, GSH, vitamin C and CAT levels and there was a significant decrease in SOD, MDA, urea and LDL levels in groups supplemented with antioxidants. There was a significant improvement in the antioxidant status in groups treated with antibiotic, anti-inflammatory, mucolytics plus antioxidants in comparison with groups treated with antibiotic, antiinflammatory and mucolytics only. The present investigation indicates those antioxidants supplementations resulted in improvement of the status of oxidative stress which is a CHARacteristic feature of respiratory diseases in horses and are helpful in treatment of such cases.

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