The current study was carried out to investigate the pharmacokinetic profile of cefquinome following a single IV injection in ten New Zealand white rabbits (2-2.5 kg body weight). Cefquinome was injected intravenously (2mg/kg body weight) and blood samples were collected before drug administration and up to 24h after injection. Cefquinome plasma concentrations were measured using HPLC (high- performance liquid chromatography). The result showed that the plasma concentration of cefquinome was 9.13 ± 0.43 µg/mL at 5min post injection then declined gradually to 0.73 ± 0.18µg/mL after 2 hours. No cefquinome concentration could be detected at 4h post injection. The major pharmacokinetic parameters (Mean ± SEM) were T1/2 λz 0.52 ± 0.05h, AUC0-∞ 9.13 ± 0.63 h*µg/mL, Cl 239.25 ±14.61 mL/h/kg, Vz 170.89 ± 9.7 mL/kg and MRT0-∞ 0.75 ±0.06 h.
(2018). PHARMACOKINETICS OF A SINGLE INTRAVENOUS INJECTION OF CEFQUINOME IN RABBITS. Mansoura Veterinary Medical Journal, 19(1), 307-319. doi: 10.21608/mvmj.2018.123540
MLA
. "PHARMACOKINETICS OF A SINGLE INTRAVENOUS INJECTION OF CEFQUINOME IN RABBITS". Mansoura Veterinary Medical Journal, 19, 1, 2018, 307-319. doi: 10.21608/mvmj.2018.123540
HARVARD
(2018). 'PHARMACOKINETICS OF A SINGLE INTRAVENOUS INJECTION OF CEFQUINOME IN RABBITS', Mansoura Veterinary Medical Journal, 19(1), pp. 307-319. doi: 10.21608/mvmj.2018.123540
VANCOUVER
PHARMACOKINETICS OF A SINGLE INTRAVENOUS INJECTION OF CEFQUINOME IN RABBITS. Mansoura Veterinary Medical Journal, 2018; 19(1): 307-319. doi: 10.21608/mvmj.2018.123540
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