Comparative studies of closantel, triclabendazole and nitroxynil on naturally infected sheep with fasciola

The present study was planned to fortitude the effects of the closantel. Triclabendazole and nitroxynil on the percent of fasciola gigantic eggs. Some hematological and biochemical profiles of the naturally infected sheep. Forty mature sheep of both sex naturally infected with fasciola gigantic were classified into four groups ( 10 animals for each). The first group (G1) was kept as non treated control. The second group ( G2) was injected(S/C) with closantel (5 mg/kg B.W.) .While the third one (G3) received triclabendazole at 12 mg /kg B.W. at once orally. The last group (G4) injected at once (S/C) with nitroxynil (10 mg/kg B.W).
Closantel (5 mg/kg B.W.). Triclabendazolen ( 12 mg/kg B.W. and nitroxynil (10 mg/ kg B.W.) induced significant decrease on total fasciolla hepatica eggs compared to control group with non significant different between the effect of tested drugs on fasciola giganticaeggs at 7, 14 and 21. The efficacy percent of closantel, triclabendazole and nitroxynil were 90 % , 100% and 100% respectively after 21 days post treatment.
Closantel (5 mg/kg B.W. ) Triclabendazole (12 mg/kg B.W.) and nitroxynil (10 mg/kg B.W.) produced a significant increase in haemoglobin level and RBCs counts and a significant decrease in total leukocytic count. The differential leukocytic count of treated groups revealed a significant decrease in neutrophils % and eosinophils %. With a significant increase in lymphocyte % and monocytes % (G3 ) at third week post treatment.
The tested drugs induced a significant increase in serum total proteins, albumin, total lipids, triglycerides. Phospholipods and HDL-c with significant decrease of LDL-c and total cholesterol at the third week post dosing in treated group compared with control group.
The effects of closantel ( 5 mg/kg B.W.) triclabendazole (12 mg/kg B.W.) and nitroxynil (10 mg/kg B.W.) on liver and kidney functions revealed a significant decrease in liver enzyms(ALP,ALT and AST) and urea formation in treated groups judged against the infected non treated grou