Objective: To evaluate the effect of multimodal analgesic drugs for alleviation of pain accompanying laparo-ovariectomy in goat. Design: Randomized controlled experimental study. Animals: Sixteen goats ageing 8-18 months and weighing 20 kg on average. Procedures: The proposed site of laparotomy in all animals was infiltrated with lidocaine hydrochloride 1% 15 minutes before surgery started. The goats were allocated into four groups of four animals each; first group (L): animals received Lidocaine infltration , second group (PL): animals received Piroxicam at a dose rate of 5 mg/kg IM, third group (PPL): animals received Piroxicam and Propofol at a dose rate of (5 mg/kg and 6 mg/kg, respectively), and finally fourth group (PPBL): animals received Butorphanol at a dose rate of 0.1 mg/kg in addition to Piroxicam- Propofol . Heart rate (HR), respiratory rate (RR), rectal temperature (RT), serum concentrations of lactate, creatinine, blood urea nitrogen (BUN), interleukin-6 (IL-6), Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were determined at baseline (15 minutes prior to surgery), directly after administration of the anesthetic agent, during surgery, and post-surgery at 30 minutes, 60 minutes, 120 minutes for 1-3 days postoperatively. Additionally, the analgesia score was monitored. Results: Heart rate, respiratory rate, Serum levels of IL 6, BUN and ALT decreased significantly in PPBL group compared to the other groups (P≤0.05). In addition, analgesia scores were significantly higher in PPBL group than the other groups (P≤0.05). Conclusion and clinical relevance: It could be concluded that the use of Propofol and Butorphanol in the analgesic protocol during laparo-ovariectomy in goats can alleviate stress and pain response and could therefore potentiate the effects of local analgesics.
(2019). Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy. Mansoura Veterinary Medical Journal, 20(4), 1-8. doi: 10.21608/mvmj.2019.20.401
MLA
. "Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy". Mansoura Veterinary Medical Journal, 20, 4, 2019, 1-8. doi: 10.21608/mvmj.2019.20.401
HARVARD
(2019). 'Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy', Mansoura Veterinary Medical Journal, 20(4), pp. 1-8. doi: 10.21608/mvmj.2019.20.401
VANCOUVER
Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy. Mansoura Veterinary Medical Journal, 2019; 20(4): 1-8. doi: 10.21608/mvmj.2019.20.401