EFFECT OF IMIDOCARB DIPROPIONATE ON FOETAL DEVELOPMENT IN RATS

Imidocarb is widely used in veterinary field as an antiprotozoal agent for the treatment of Babesiosis and Anaplasmosis. from this view, The toxicity of imidocarb was tested in female rat and their foeti. The study was applied on fourty female mature rats which divided into four groups, 1st and 2nd groups were kept as control (injected normal saline intramuscularly on 6th and 10th day of pregnancy respectively), while the third group was injected by imidocarb (0.4 mg/kg b.wt.) on the 6th day of pregnancy , while the fourth group was injected with the therapeutic dose of imidocarb (.4 mg/kg b.wt) on the 10th day of pregnancy. Teratological and biochemical parameters alterations were estimated in this study. The results showed that the therapeutic dose of imidocarb on 6th day induced decrease in foetal body weight , increase the percent of absorbed foeti , decrease live foeti , and showed abnormalities in kidney (narrowing in renal pelvis) and heart (thickening in the ventricular wall) ,The results showed also absence and or incomplete ossification of cranium ,xiphistrenebrae and caudal vertebrae. Histopathological examination revealed partial destruction of hepatic parenchyma in liver of dams, while massive peri-glomular mononuclear cells infiltrtion in renal cortex in kidney of dams. Biochemical analysis evoked a significant increase in serum ALT and AST, Urea and creatinine, however it induce a significant decrease in serum total protein . So, we must increase the attention paid to the usage of imidocarb in pregnant animals.