Mansoura University, Faculty of Veterinary MedicineMansoura Veterinary Medical Journal1110-721920420191201Evaluation of Multimodal Anesthetic Drugs Combination in Goats undergoing laparo-ovariectomy1811807410.21608/mvmj.2019.20.401ENJournal Article20191015<strong><em>Objective:</em></strong><em> To evaluate the effect of multimodal analgesic drugs for alleviation of pain accompanying laparo-ovariectomy in goat</em><em>. </em><br /> <strong><em>Design:</em></strong><em> Randomized controlled experimental study</em><em>.</em><br /> <strong><em>Animals:</em></strong><em> Sixteen goats ageing 8-18 months and weighing 20 kg on average</em><em>.</em><br /> <strong><em>Procedures:</em></strong><em> The proposed site of laparotomy in all animals was infiltrated with lidocaine hydrochloride 1% 15 minutes before surgery started. The goats were allocated into four groups of four animals each; first group (L): animals received Lidocaine infltration , second group (PL): animals received Piroxicam at a dose rate of 5 mg/kg IM, third group (PPL): animals received Piroxicam and Propofol at a dose rate of (5 mg/kg and 6 mg/kg, respectively), and finally fourth group (PPBL): animals received Butorphanol at a dose rate of 0.1 mg/kg in addition to Piroxicam- Propofol . Heart rate (HR), respiratory rate (RR), rectal temperature (RT), serum concentrations of lactate, creatinine, blood urea nitrogen (BUN), interleukin-6 (IL-6), Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) were determined at baseline (15 minutes prior to surgery), directly after administration of the anesthetic agent, during surgery, and post-surgery at 30 minutes, 60 minutes, 120 minutes for 1-3 days postoperatively. Additionally, the analgesia score was monitored</em><em>.</em><br /> <strong><em>Results:</em></strong><em> Heart rate, respiratory rate, Serum levels of IL 6, BUN and ALT decreased significantly in PPBL group compared to the other groups (P≤0.05). In addition, analgesia scores were significantly higher in PPBL group than the other groups (P≤0.05).</em><br /> <strong><em>Conclusion and clinical relevance:</em></strong><em> It could be concluded that the use of Propofol and Butorphanol in the analgesic protocol during laparo-ovariectomy in goats can alleviate stress and pain response and could therefore potentiate the effects of local analgesics.</em>https://mvmj.journals.ekb.eg/article_118074_ffe0e89d0c30a68db9b3f923e42726bc.pdfMansoura University, Faculty of Veterinary MedicineMansoura Veterinary Medical Journal1110-721920420191225Efficacy of Ginger and Nutritox® in counteracting aflatoxin effects on white Pekin ducklings212814554610.21608/mvmj.2019.20.404ENWalaaAbu El-ElaVeterinary Teaching Hospital, Faculty of Veterinary Medicine Mansoura University, Mansoura 35516, Egypt.KamelAbou.ElazmDepartments of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine Mansoura University, Mansoura 35516, EgyptSanaaAwadDepartments of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine Mansoura University, Mansoura 35516, EgyptJournal Article20191016Objective: To evaluate the anti-aflatoxin effects of Ginger and Nutritox® in white Pekin ducklings. Design: Randomized experimental study Animals: Ninty- one-day-old white Pekin ducklings. Procedures: Ducklings were alienated randomly into six equal groups, each group in 3 replicates (each replicate, n=5). Control group G1) was fed on commercial broiler basal diet without any medications, while other experimental groups, namely 2, 3, 4, 5 and 6 were received diet containing: G2) basal diet (BD) + 300 ppb AF (aflatoxin); G3) BD + 300 ppb AF + 250 mg kg-1 Gr (Ginger); G4) BD +300 ppb AF +1gm/kg feed Nutritox®; G5) BD + 250 mg kg-1 mg/kg of B.W Gr; G6) BD + 1gm/kg feed Nutritox® during study (1-14) days respectively. Results: Results showed that, addition of Ginger and Nutritox® ameliorated in different degrees the adverse effects of aflatoxin and improved growth performance and some serum biochemical parameters [Aspartate aminotransferase (AST), alanine aminotransferase (ALT) and Alkaline phosphatase (ALP)]. They hasten the recovery of antioxidant enzymes (MDA and GSH) in tissue to their normal levels during certain periods of our experiments. Histopathological liver changes run in the same track with biochemical results. Results revealed that administration of Ginger or Nutritox® in diet prevents and/or reduce some adverse effects of aflatoxin in ducks. Conclusion and clinical relevance: Our study indicates that ginger, an alternative natural product can provide protection against aflatoxin as Nutritox®.https://mvmj.journals.ekb.eg/article_145546_0a9ecf212bf2495cb6a9efc8087a9d6d.pdfMansoura University, Faculty of Veterinary MedicineMansoura Veterinary Medical Journal1110-721920420191225The Effect of colour temperature of light on egg production parameters and gene expression pattern of Heat Shock Protein 27 in layers91414554910.21608/mvmj.2019.20.402ENHudaEL-EmamDepartment of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.AhmedAteyaDepartment of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, EgyptImanEL- ArabyDepartment of Husbandry and Development of Animal Wealth. Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.UsamaAbou-IsmailDepartment of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.0000-0003-3080-6999MohamedFoudaDepartment of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.Journal Article20191015Objective: To evaluate the effects of different light colour temperatures on egg production parameters and heat shock protein gene expression (HSP 27) in Fayoumi chicken layers. Animals: 165 Fayoumi healthy pullets (17 weeks). Design: Randomized-controlled experimental study. Procedures: The birds were exposed to natural day light with photoperiod 12L: 12D, from 19th week, lighting schedule was gradually increased half an hour every week till it reached 16L:8D lighting schedule at laying at 24 weeks of age. At laying, the birds were allocated into three groups at a density of 9 birds/m2. The first group (control group) was exposed to cool white LED light (day light) (6500 kelvin). The second group was exposed to very cool white LED light (sky blue light) (10000 kelvin). The third group was exposed to warm white LED light (yellow light) (2700 kelvin) till the end of the experiment. Eggs were collected daily; egg number, weight and mass were recorded for each group. Liver samples were collected for RNA extraction. Results: The results showed that egg number, egg weight and egg mass were significantly increased in blue light group (P ≤ 0.05) and HSP 27 gene expression was significantly upregulated (P ≤ 0.05) in this group of chicken in comparison to the control group. Conclusion and clinical relevance: It is concluded that the blue LED light may be suitable for use in layer farms to optimize reproductive efficiency of birds.https://mvmj.journals.ekb.eg/article_145549_942bd506bf751ff8ab2ef08c421fd32e.pdfMansoura University, Faculty of Veterinary MedicineMansoura Veterinary Medical Journal1110-721920420191225The effects of Dried Guava Waste and Dried Olive Cake as Substitutes for Alfalfa on Rabbit Farm Profit152014556110.21608/mvmj.2019.20.403ENNohaWaheedDepartment of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt, P.O.
35516SanadAttalahDepartment of Animal Husbandry, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.RagabDarwishDepartment of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt, P.O.
35516MohamedFoudaDepartment of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt, P.O.
35516Journal Article20191116Objectives: To evaluate the effects of adding dried guava waste and dried olive cake as substitution of alfalfa in diet on rabbit farm profits. Design: Randomized controlled experimental study. Animals: Thirty-six Hypluse white rabbits at the age of 33 days with an average body weight of 696.6 g. Procedures: Rabbits were allocated into four groups of nine animals each. Group 1 (Control group) was fed on a basal rabbit diet. Group 2 was fed on a diet containing 5% dried guava waste (DGW) as a substitute for alfalfa, Group 3 which was fed on a diet containing 5% dried olive cake (DOC) as a substitute for alfalfa, and Group 4 which received a diet containing combination of both 5% DGW and 5% DOC as a substitute for alfalfa. Results: The addition of 5% DGW and 5% DOC in diets of rabbits as a substitute for alfalfa resulted in improvements in body weights of animals when compared to the basal diets, whereas the inclusion of the two materials in the diet of rabbits lowered the body weights of animals. The feed intake in group (two and three) was lower than that of the control group. Groups (two and three) showed lower values of feed costs, total variable costs and higher total return, and thus had higher values of profits when compared to the control group. Group four showed higher total variable costs and total costs, while the total return was the lowest and consequently the profit was the lowest also. Conclusion and clinical relevance: The addition of either 5% DGW or DOC in diets of rabbits to substitute a portion of alfalfa appeared satisfactory for rabbit farm profit as their profit were higher than control group by 5.37 and 11.74 LE respectively, while their combination did not appear to be useful and therefore was not recommended.https://mvmj.journals.ekb.eg/article_145561_f7fcba9d435511b5937b2a49b8952ca8.pdfMansoura University, Faculty of Veterinary MedicineMansoura Veterinary Medical Journal1110-721920420191225Assessment of a multimodal analgesia protocol in goats undergoing claw amputation374614557110.21608/mvmj.2019.20.406ENUsamaFekryVeterinarin, Veterinary Sector, Dakahlia, EgyptEsamMosbahDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, 35516 Mansoura, EgyptAdelZaghloulDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, 35516 Mansoura, EgyptAwadRizkDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, 35516 Mansoura, EgyptJournal Article20190924Objective: To evaluate the anti-nociceptive, sedative and behavioral effect of multimodal analgesic drugs in goat's undergoing unilateral claw amputation. Design: A randomized experimental design. Animals: Sixteen goats were randomly assigned into 4 groups (4 each). Procedures: Animals used in this study were randomly assigned into 4 groups, four animals for each group. All goats were anaesthetized by intravenous regional anesthesia (IVRA) of the right forelimb cephalic vein with 2% lidocaine in a dose of 3mg/kg body weight (BW) before surgery. Administration of carprofen (50 mg/ml) at a dose 0.1 mg/kg BW took place before surgery on day 0 and was then repeated once daily for another 3 consecutive days postoperatively in groups Lidocaine (L), carprofen_lidocaine (CL), carprofen – romifidine - lidocaine (CRL), and carprofen – romifidine - butorphenol - lidocaine (CRBL). Heart rate (HR), respiratory rate (RR), rectal temperature (RT), serum IL-6 level, sedation score, and lameness score were determined at preset time intervals and the animals’ behavior was recorded. Results: The mean average of HR, RR and RT in IVRA treated animals was significantly increased until the end of surgery followed by gradual decrease up to 90 min post-surgery. In CRL and CRBL it showed a significant decrease compared to controls. There was a significant decrease in lameness score in CRL and CRBL treated animals from 30 min until 2 hours and for 3 days post-surgery. After injection of romifidine it showed a significant decrease of IL-6 levels compared to lidocaine and CL treated animals. Conclusion and clinical relevance: It was concluded that, the use of romifidine and buterphanol in the analgesic protocol during claw amputation in goats, alleviate pain response and potentiate the analgesic effects of IVRA. Addition of carprofen to the analgesic protocol can be used for long- term treatment of orthopedic pain in goats without complications.https://mvmj.journals.ekb.eg/article_145571_e7ce5b3744e9f3a21007a8220ebefb7c.pdfMansoura University, Faculty of Veterinary MedicineMansoura Veterinary Medical Journal1110-721920420191225Effect of complete and partial capsulotomy on the renal function tests and oxidative stress markers in rats undergoing ischemia-reperfusion injury293614557810.21608/mvmj.2019.20.405ENYomnaKhaterMedical Experimental Research Center, Faculty of Medicine, Mansoura University, Mansoura, P.O. 35516, Egypt.AwadRizkDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, P.O. 35516, Egypt.MohamedSaadDepartment of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Mansoura, P.O. 35516, Egypt.AdelZaghloulDepartment of Surgery, Anesthesiology and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, P.O. 35516, Egypt.Journal Article20190914Objective: To compare the effect of complete and partial renal capsulotomy on the renal function tests and oxidative stress markers in rats undergoing ischemia-reperfusion injury. Design: Randomized controlled experimental study. Animals: A 60 Spraque-dawely rats weighing 180 ± 50 g. Procedures: Rats were divided into 3 groups in triplicate (6 each). In addition, 6 rats were subjected to blood and renal tissues sampling for estimation of normal parameters. Group 1 (Positive control): ischemia reperfusion (IR) injury; Group 2: Complete capsulotomy + I R; Group 3: Partial capsulotomy + IR. Six rats from each group were sacrified at 2, 7 and 14 days post- surgery. Results: The complete capsulotomy induced a significant decrease in the serum creatinine at 2 and 7 days post- capsulotomy in comparison with partial capsulotomy (P < 0.05), whereas at 14 days, the partial capsulotomy induced the significant decrease (P < 0.05). Complete capsulotomy showed a significant improvement in creatinine clearance in comparison with partial capsulotomy at 2, 7 and 14 days post- surgery (p < 0.05). At 2 and 7 days, BUN of IR+ Capsulotomy group showed a significant decrease (P < 0.05) compared to the other groups, while at 14 days partial capsulotomy, the serum BUN reached to the normal value. Serum sodium level showed a significant decrease (P < 0.05) at 2 days after partial capsulotomy, and at 14 days after complete capsulotomy (P < 0.05). Nitric oxide level in IR + partial capsulotomy group showed a significant decrease at 7 and 14 days (P < 0.05). Results of MDA of IR+ partial capsulotomy groups showed a significant decrease (P < 0.05) compared to the IR+ compete capsulotomy groups at 2,7 and 14 days. Conclusion and clinical relevance: The partial capsulotomy ameliorates could improve serum creatinine, BUN and could lower the oxidative stress at 14 days. Partial capsulotomy could also improve the renal tissues at both short and long-term. So this study indicates the importance of the presence of intact renal capsule for ischemic acute kidney injuryhttps://mvmj.journals.ekb.eg/article_145578_5e48fe44d3cd21ecedf1c7ad98b858f7.pdf