TY - JOUR ID - 281368 TI - protective and therapeutic effect of omega_3 against nephrotoxicity JO - Mansoura Veterinary Medical Journal JA - MVMJ LA - en SN - 1110-7219 AU - farid, zahraa magdy AD - faculty of veterinary medicine mansoura university , biochemistry department Y1 - 2023 PY - 2023 VL - IS - SP - EP - KW - Cisplatin KW - omega-3 KW - renal KW - Rats KW - toxicity DO - 10.21608/mvmj.2023.185092.1128 N2 - Objective: to determine the therapeutic and protective effects of omega 3 on the cisplatin induced renal toxicity in albino rats. Design: Randomized controlled study. Animal: 50 adult male albino rats weighting (200-230 g). Procedures: There was five groups of rats for control, omega 3 ingested, cisplatin injected, cisplatin injected then treated with omega 3 and omega 3 ingested then injected with cisplatin. After 5 weeks of follow up the serum levels of creatinine, uric acid, LDH, LDL, TG, TC, MAD, SOD, CAT and GSH were determined. Results: there was significant (Pvalue<0.001) increase in serum levels of creatinine, uric acid, LDH, LDL, TG, TC and MAD and decrease in levels of SOD, CAT and GSH in the cisplatin injected animals without omega 3 ingestion. However these parameters were improved in the omega 3 treated animals and especially in the protective group that gave values resembling the control groups. Conclusion and clinical relevance: We concluded that omega 3 is a very useful
protective and to some extent therapeutic agent against cisplatin induced renal
toxicity. UR - https://mvmj.journals.ekb.eg/article_281368.html L1 - ER -